Medical uses of ozonized oils, an up-date

Abstract

Early evidence on the clinical use of ozonated oils first appear in scientific literature in
1859. This paper reviews the general and main clinical applications of ozonated oils
that have appeared in scientific literature between 1859-2011. The oxidation products
generated after the reaction of ozone with fatty acids and other substrates can acts as
a germicide, immune stimulantand tissue restoration agent. The biological activities
and stability of the ozonated oilsallows the development of standard formulations that
deliver the benefits of ozone, supported by pre-clinical and clinical studies.The main
clinical studies that support t he u se of ozonized oils apply ozonizedsun flower oil
orozonizedolive oil in different clinical conditions. The applications are essentially for
external use, however there is evidence of immune-stimulating and repaireffects when
used orally. A deep study of the biological effects of various formulations already on
the mar ket will support the scientific b asis of the use of ozoniz ed o i l in differen t
pathologies.