Growth factors derived from platelet and its applications in regenerative medicine. Potential use of ozone as activator

Abstract

A n ewer treatment, autologous p l a telet - r ich plas ma (PRP), r e presents a gre a ter
sim i l arity to the n atura l healing process as a composite of multiple growt h f actors ,
is safe due to its autologous nature, and is produced as needed from patient blood.
PPR is an concentration of platelets and growth factors, including transforming growth
factor-beta (TGF-b), vascular endothelial growth factor (VEGF), and platelet derived
growth facto r (PDGF). The enhancement of tis sue h e a ling by the placeme n t of
supr aphysi o l o g ic conc e n tration of autologous p latel e ts at the site of tissue inj u r y
or s u r g e r y i s su p p o r ted by bas i c science and c linical studies. Due to the increased
concentration and release of these factors, PPR can potentially enhance the recruitment
and proliferation of s tem cells and endothel i a l cell s. O zone can pr o mote platelet
aggrega tio n a n d release of grow f a ctors wi th both m it o g enic and c h e motac ti c
proper tie s. In additio n t o us e in the t r eat ment o f chro n ic skin a nd sof t ti ssue
ulcera ti o ns , a ppli ca ti o n of thi s method includ e per i odontal and o ral s u rgery,
maxillofacial surgery, ortho pedic an d trauma surgery, cos metic and plastic surgery,
spina l surgery, heart by pass surgery, and burns. A bette r understanding of pla telet
function and appropriate clinical use is essential in achieving the desired outcomes of
platelet-rich concentrate in clinical applications.