Ozone therapy in traumatology and burns treatment

Abstract

This review summarizes the bases of the use of ozone in wound healing in patients
sufferin g from trauma or burns. Di fferent clinical assays had shown that lo cal or
systemic application of oxygen-ozone therapy in wounds and superficial scalds results
in accelerated cleansing of a wound from necrotic tissues without generate necrosis.
In addition to the well know germicide effect of ozone, its application can stimulate the
local tissue regeneration, the local immune response and can control the inflammatory
reaction. The quick management of pain and edema, the reduction of epithelialization
time and the better graft retention are part of the benefit of the integrative use of ozone
in traumatology and burns treatment.
Bases on the Russ ian clinical experience the indication, contrai ndication, protocols
and specific care during the application of this therapy was described. The systemic
ozone therapy conducted af ter an analy sis of the oxidative str ess status in those
patients was referred. The concept of integration of ozone therapy as part of the routing
care of the wounds is expressed. In this context the application of ozone offer many
advantages, for instance: ozone reactivating the oxygen homeostasis, can increase
the antioxidant ac tivity of blood pla sma, im prove periph eral circu l atio n and
microcircu l atio n, induce homeost asis compens ation, and modulate the antiinflammatory
and immune response in addition to their detoxification effects